Peptides

1.The gray-market compounds (retatrutide, BPC-157, TB-500) that SF tech people inject to get lean and heal faster. Casually mentioning your stack on X is the flex: it signals money, optimization discipline, and risk tolerance in one sentence.

He opened the date by listing his peptide stack and his Whoop recovery score.

01Origin

Peptide use came out of bodybuilding and biohacking forums, but it became SF tech-culture discourse in 2025 as gray-market vendors made compounds like retatrutide (an unapproved Eli Lilly GLP-1 triple agonist still in Phase 3 trials) and BPC-157 ("the healing peptide") easy to buy as "research chemicals." The San Francisco Standard's September 2025 piece "Everyone has a Chinese peptide dealer now" documented the scene, with one SF doctor reporting roughly a fifth of weight-loss patients on retatrutide.

The meme phase peaked from late 2025 into 2026: posting your stack, "Wolverine stack" jokes (BPC-157 plus TB-500), vendor drama over fake retatrutide, Andrew Huberman calling retatrutide a coming "trillion-dollar drug" on TBPN, Eli Lilly suing gray-market sellers, and the abrupt shutdown of leading vendor Peptide Sciences. Each scandal only raised the topic's status.

Peptides are uggmaxxing's mirror image: where the uggmaxxer deletes the body from the optimization loop, the peptide guy makes the body the optimization loop. Same impulse, opposite sign. (This entry documents the discourse; nothing here is medical advice, and most of these compounds are unproven in humans at these uses.)

02Notable sightings

Ben Greenfield · @bengreenfield · view on X
The recent peptide craze is funny. To me, these are old news. I’ve been writing about them since 2016. I literally coined the term “Wolverine stack” (BPC-157 and TB-500). And I was late to the game… …bodybuilders have been immersed in peptides since the early 2000s. But suddenly peptides are the sexiest thing out there. Is it because they have odd names? Is it because people find it novel and interesting to use needles? Is it because people are bored of supplements? What do you think?

🅿️ · @the_P_God · view on X
Peptide bros in 15 years after abusing black market Chinese “peptides” and using a LLM to develop stacks

JP Sears · @AwakenWithJP · view on X
When Bros First Learn About Peptides

TBPN · @tbpn · view on X
“This is going to be a trillion-dollar drug.” @hubermanlab says retatrutide is the peptide that’s about to “change everything.” Currently in a Phase III clinical trial in humans, retatrutide caused up to one-third body weight loss in just six months, with some degree of muscle sparing. “The bodybuilding community has been onto this for a long time.” “Then it shows up in Hollywood. Everyone lies or avoids answering the question of how they got so jacked. They talk about eating chicken breasts, and they’re actually taking growth hormone, Winstrol, and retatrutide.” “We are looking at a potential change in the laws around peptides such that buying peptides would become illegal. I think this is a terrible idea, but the motivation behind this is largely because Eli Lilly owns the patent.” “Lilly would like to protect the domain over that patent. This is going to be a trillion-dollar drug.”

Tom Howard · @_TomHoward · view on X
PSA: Retatrutide from Peptide Sciences recently does not contain Retatrutide per independent testing.

Hims House · @himshouse · view on X
🚨 BREAKING: PEPTIDE SCIENCES HAS SHUT DOWN - Peptide Sciences was a leading vendor of peptides like BPC-157, TB-500, and retatrutide - Website announcement says the decision has been made "voluntarily" $HIMS $LLY $NVO

More sightings on X →

03Spread the ism

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Peptides

01Origin

02Notable sightings

03Spread the ism

04See also